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Drug: Estradiol
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Total 6522 results found since Jan 2013.
Interaction Between EE2/DSG and LPV/r in HIV+ Adolescents Interaction Between EE2/DSG and LPV/r in HIV+ Adolescents
Could oral contraceptives containing ethinyl estradiol/desogestrel compromise the effectiveness of lopinavir/ritonavir-based therapy?JAIDS: Journal of Acquired Immune Deficiency Syndromes
Source: Medscape Hiv-Aids Headlines - August 24, 2016 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news
Fostemsavir and Ethinyl Estradiol Drug Interaction Fostemsavir and Ethinyl Estradiol Drug Interaction
This article provides guidance regarding the co-administration of fostemsavir with hormonal therapies containing ethinyl estradiol among people living with HIV.HIV Medicine
Source: Medscape Hiv-Aids Headlines - June 16, 2023 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news
Gonadotropin and Sex Steroid Levels in HIV-Infected Premenopausal Women and Their Association With Subclinical Atherosclerosis in HIV-Infected and -Uninfected Women in the Women's Interagency HIV Study (WIHS).
Conclusions:HIV-infected women had reduced estrogen and androgen compared with HIV-uninfected premenopausal women. T deficiency is linked with carotid artery stiffness, regardless of immune suppression, whereas E2 deficiency is linked with carotid stiffness among immunocompromised HIV-infected premenopausal women. Further research is warranted to understand the impact of endocrine dysregulation on the accelerated cardiovascular disease risk in HIV-infected women.
PMID: 23418313 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 15, 2013 Category: Endocrinology Authors: Karim R, Mack WJ, Kono N, Tien PC, Anastos K, Lazar J, Young M, Cohen M, Golub E, Greenblatt RM, Kaplan RC, Hodis HN Tags: J Clin Endocrinol Metab Source Type: research
Estrogen May Enhance Toll-Like Receptor 4-Induced Inflammatory Pathways in People With HIV: Implications for Transgender Women on Hormone Therapy
ConclusionsOur in vitro data suggest that estrogen exposure may enhance innate immune activation in PWH. Further examination is needed to fully understand the complex interactions of FHT, HIV, and CVD in TW, and determine optimal FHT regimens or supplementary treatments aimed at reducing excess immune activation.
Source: Frontiers in Immunology - June 3, 2022 Category: Allergy & Immunology Source Type: research
Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice
Aging (Albany NY). 2022 Jul 12;14(undefined). doi: 10.18632/aging.204166. Online ahead of print.ABSTRACTIn the U.S. about half of the HIV-infected individuals are aged 50 and older. In men living with HIV, secondary hypogonadism is common and occurs earlier than in seronegative men, and its prevalence increases with age. While the mechanisms(s) are unknown, the HIV-1 trans-activator of transcription (Tat) protein disrupts neuroendocrine function in mice partly by dysregulating mitochondria and neurosteroidogenesis. We hypothesized that conditional Tat expression in middle-aged male transgenic mice [Tat(+)] would promote ag...
Source: Aging - July 13, 2022 Category: Biomedical Science Authors: Alaa N Qrareya Fakhri Mahdi Marc J Kaufman Nicole M Ashpole Jason J Paris Source Type: research
Sex hormones, the stool microbiome, and subclinical atherosclerosis in women with and without HIV
CONCLUSION: Serum sex hormones are significant predictors of stool microbiome diversity and composition, likely due in part to metabolic interactions. The gut microbiome may play a role in estrogen-related cardiovascular protection.PMID:37643897 | DOI:10.1210/clinem/dgad510
Source: Atherosclerosis - August 29, 2023 Category: Cardiology Authors: Brandilyn A Peters David B Hanna Yi Wang Kathleen M Weber Elizabeth Topper Allison A Appleton Anjali Sharma Howard N Hodis Nanette Santoro Chantal Guillemette Patrick Caron Rob Knight Robert D Burk Robert C Kaplan Qibin Qi Source Type: research
Microstructural alterations of trabecular and cortical bone in long-term HIV-infected elderly men on successful antiretroviral therapy
Conclusion:HIV-infected elderly men on successful ART have trabecular and cortical bone microstructure alterations associated with higher bone resorption, despite adequate vitamin D supplementation.
Source: AIDS - October 4, 2014 Category: Infectious Diseases Tags: Clinical Science Source Type: research
Transgender women, hormonal therapy and HIV treatment: a comprehensive review of the literature and recommendations for best practices.
CONCLUSIONS: There are insufficient data to address DDIs between ART and feminizing hormone regimens used by TGW. There is an urgent need for further research in this area, specifically pharmacokinetic studies to study the direction and degree of interactions between oral, injectable and transdermal estradiol and ART. Clinicians need to be vigilant about possible interactions and monitor hormone levels if concerns arise. More research is also needed on the provision of hormone therapy and gender-affirming care on the long-term health outcomes of HIV-positive TGW.
PMID: 27431475 [PubMed - in process]
Source: Journal of the International AIDS Society - July 21, 2016 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
GSE100094 Fluctuations in sex hormones affect ex vivo HIV infection in cervical mucosa and mucosal immunity
This study evaluated if serum estradiol (E2) and progesterone (P4) levels predict the ex vivo cervical tissue HIV infection, tissue immune environment and transcriptome. Cervical mucosa and peripheral blood samples were collected from subjects undergoing total hysterectomies. Tissue explants were challenged with HIV-1BaL and infection was monitored in the supernatants by HIV gag qRT-PCR. Serum E2 and P4 concentrations were measured by radioimmunoassay. Blood and tissue T cell phenotypes were characterized by flow cytometry. Tissue responses to HIV exposure were measured by Luminex. Tissue transcriptome in an unchallenged p...
Source: GEO: Gene Expression Omnibus - June 15, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Evaluating the menopausal transition with the STRAW + 10 in a Brazilian cohort of women with HIV, 2015-2016
CONCLUSIONS: The present results support use of the STRAW + 10 to characterize the menopausal transition of WWH with good clinical and immunological control.PMID:33709858 | DOI:10.1080/13697137.2021.1889501
Source: Climacteric - March 12, 2021 Category: Geriatrics Authors: E M Jalil R M Domingues M Derrico M B Dias A C V Andrade V S O Rocha S Nazer M Feitosa S W Cardoso V G Veloso R K Friedman B Grinsztejn Source Type: research
Blood transcriptome analysis revealed the crosstalk between COVID-19 and HIV
ConclusionIn this study, we provide potential molecular targets, signaling pathways, small molecular compounds, and promising biomarkers that contribute to worse COVID-19 prognosis in patients with HIV, which might contribute to precise diagnosis and treatment for HIV-infected COVID-19 patients.
Source: Frontiers in Immunology - October 28, 2022 Category: Allergy & Immunology Source Type: research
Innate and adaptive anti-HIV immune responses in the female reproductive tract
Abstract: The mucosal surface of the female reproductive tract (FRT) is the primary site of transmission for a plethora of sexually transmitted infections, including human immunodeficiency virus (HIV), that represent a significant burden upon womens’ health worldwide. However, fundamental aspects of innate and adaptive immune protection against HIV infection in the FRT are poorly understood. The FRT immune system is regulated by the cyclical changes of the sex hormones estradiol and progesterone across the menstrual cycle, which as we have hypothesized, leads to the creation of a window of vulnerability during the secret...
Source: Journal of Reproductive Immunology - February 23, 2013 Category: Allergy & Immunology Authors: Marta Rodriguez-Garcia, Mickey V. Patel, Charles R. Wira Source Type: research
